Airway goblet cells secrete pro-inflammatory cytokines, chemokines, and growth factors
T Tanabe, BK Rubin - Chest, 2016 - Elsevier
Background IL-13 is a T-helper cell type 2 cytokine that plays an important role in the
pathogenesis of asthma. IL-13 exposure for 14 days transforms cultured normal human
bronchial epithelial cells to a goblet cell phenotype. We hypothesized that goblet cells would
have a different pattern of cytokine secretion than ciliated airway cells. Methods Normal
human bronchial epithelial cells were grown for 14 days at an air-liquid interface with IL-13
to produce a goblet cell phenotype (n= 4) or with phosphate-buffered saline to produce …
pathogenesis of asthma. IL-13 exposure for 14 days transforms cultured normal human
bronchial epithelial cells to a goblet cell phenotype. We hypothesized that goblet cells would
have a different pattern of cytokine secretion than ciliated airway cells. Methods Normal
human bronchial epithelial cells were grown for 14 days at an air-liquid interface with IL-13
to produce a goblet cell phenotype (n= 4) or with phosphate-buffered saline to produce …
