Dry eye disease is a common and multifactorial disease with a high prevalence worldwide.
Water loss, reduced expression of glycocalyx mucins, and loss of goblet cells secreting gel-
forming mucins are hallmarks of dry eye disease. Mucins are large and complex heavily
glycosylated proteins. Their organization in the tear film remains unclear, but they play a key
role to protect and maintain integrity of the ocular surface. Mice have been extremely
valuable mammalian models with which to study ocular physiology and disease, and to …